Endocrine Abstracts

A 58-year-old female presented to Urology clinic after an abdominal ultrasound revealed a right sided mass. She had a 9 year history of hypertension which had been difficult to control despite treatment with six agents. She also had a history of Type 2 Diabetes Mellitus and Hyperlipidaemia. CT Thorax/Abdomen/Pelvis reported a 20 cm right renal mass with areas of calcification and following MDT discussion the diagnosis of renal cell carcinoma was made. An open right radical nep...

A 38-year male with background history of Tetralogy of Fallot which had been surgically corrected, presented with symptomatic supraventricular tachycardia in July 2015. This required amiodarone therapy. Thyroid function was normal prior to starting amiodarone. Amiodarone therapy was discontinued in July 2017 when he converted to sinus rhythm. Seven months after stopping treatment, he presented to A&E with signs and symptoms of hyperthyroidism. His TSH was <0.03 mU/l (0...

Background: Bariatric surgery is currently the most effective treatment for weight loss. Its metabolic effects of weight loss and improvement of type 2 diabetes are mediated mainly through the postprandial elevation of gut hormones such as GLP-1, which suppresses food intake and improves insulin secretion.Aim: To characterize the longitudinal changes in fasting and postprandial secretion of glucose, insulin and gut hormones (GLP-1 and GIP) in patients be...

Background: Roux-en-Y gastric bypass (RYGB) leads to effective and sustained weight loss whereas a Very-Low-Calorie diet (VLCD) is normally plagued by weight regain over time. Changes in gut hormones following each intervention may play a role. The aim of this study was to investigate gut hormone responses after 4 weeks of RYGB and VLCD.Methods: We prospectively recruited 21 volunteers with obesity and type 2 diabetes undergoing RYGB, and a matched cohor...